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. 2020 Dec 3;5(23):e140169. doi: 10.1172/jci.insight.140169

Figure 4. TP-0903 overcomes drug resistance due to bone marrow microenvironment–mediated factors.

Figure 4

(A) Inhibition of MOLM13 cell viability ± coculture with HS5-GFP MSCs (MTT assay, 72 hours, n = 24). (B) Cytokine/chemokines/growth factors secreted by HS5-GFP cells (Luminex multiplex assay, n = 2). (C and D) Growth inhibition of MOLM13 (MTT assay, 72 hours, n = 12) (C) or 7-day MV4-11 CFU assay (n = 4) (D) treated with indicated TKI ± cytokine/chemokine/growth factor support. P values were determined using 1-way ANOVA (P < 0.0001) with Tukey multiple comparison test, with specific P values indicated within the figure.