Figure 7.

Lipolysis was affected in tissue-specific manner by ALY688. In Epididymal (Epid) adipocytes, isoproterenol (Iso)-stimulated lipolysis increased (a), whereas no effect of ALY688 (100 and 300 nM) was detected in Sc Ing (b) adipocytes either under basal (Bas) or Iso-stimulated conditions. Similarly, HSL phosphorylation was elevated in Epid (c), but not in Sc Ing (d) adipocytes. Different letters denote statistical significance (p < 0.05). Two-way ANOVA, n = 4 for glycerol release and n = 2 for HSL content and phosphorylation