Figure 3.

Circ_0001785 inhibits breast cancer progression in vivo. (a) The circ_0001785 overexpression and control T47D cells were inoculated in nude mice, and mouse weight and tumor volume were monitored every day. (b) Tumor mass of T47D tumor xenograft-induced nude mice after 14 d of treatment. (c) The circ_0001785 overexpression and control MDA-MB-231 cells were inoculated in nude mice, and mouse weight and tumor volume were monitored every day. (d) Tumor mass of MDA-MB-231 tumor xenograft-induced nude mice after 14 d of treatment. (e-f) Expressions of KI67, PCNA, MMP7 and MMP9 in tumor tissues inoculated with T47D cells were detected by western blot analysis. GAPDH was used as the loading control. (g-h) Expressions of KI67, PCNA, MMP7 and MMP9 in tumor tissues inoculated with MDA-MB-231 cells were detected by western blot analysis. GAPDH was used as the loading control. **p < 0.01 and ***p < 0.001 vs. Mock