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. 2020 Oct 15;19(21):2811–2825. doi: 10.1080/15384101.2020.1824717

Figure 9.

Figure 9.

Circ_0001785 regulates SOCS3 expression via inhibiting miR-942. (a) The expressions of SOCS3 in breast cancer cells transfected with miR-942 overexpression plasmid and circ_0001785 overexpression vector were detected by qRT-PCR. ***p < 0.001 vs. miR-NC mimic; ###p < 0.001 vs. pcDNA-NC. (b) The expressions of SOCS3 in breast cancer cells transfected with miR-942 overexpression plasmid and circ_0001785 overexpression vector were detected by western blot analysis. ***p < 0.001 vs. miR-NC mimic; ###p < 0.001 vs. pcDNA-NC. (c) RIP assay revealed the enrichment of circ_0001785, miR-942 and SOCS3 on Ago2. ***p < 0.001 vs. Anti-IgG. (d) Expressions of SOCS3 in T47D and MDA-MB-231 cells were detected by western blot analysis. **p < 0.01 and ***p < 0.001 vs. pcDNA-circ_0001785. (e) Expressions of SOCS3 in tumor tissue from mice were detected by western blot analysis. **p < 0.01 and ***p < 0.001 vs. circ_0001785+ NC