Table 1.
The roles of lncRNAs in cancer
| LncRNA | Oncogene/TSG | Cancer | Effect | Mechanism | Ref |
|---|---|---|---|---|---|
| DANCR | Oncogene | Prostate | ↑Invasion, metastasis | ↓ TIMP 2/3 transcription | [72] |
| MALAT1 | Oncogene | Thyroid | ↑Angiogenesis | ↑FGF2 secretion | [73] |
| LUCAT1 | Oncogene | Breast | ↑Stemness | As a miR-5582-3p sponge | [74] |
| HOTTIP | Oncogene | Ovarian | ↑Immune escape | ↑PD-L1 transcription | [75] |
| PVT1 | Oncogene | Gastric | ↑Angiogenesis | ↑VEGFA transcription | [76] |
| HOTAIR | Oncogene | Liver | ↑Stemness | ↓SETD2 transcription | [77] |
| SLNCR1 | Oncogene | Melanoma | ↑Invasion | ↑MMP9 transcription | [78] |
| IGFBP4–1 | Oncogene | Lung | ↑Proliferation, metastasis | ↑Aerobic glycolysis | [79] |
| HULC | Oncogene | Liver | ↑Angiogenesis | ↑SPHK1 transcription | [80] |
| GAS5 | TSG | Cervical | ↓Metastasis, ↑Apoptosis | NA | [81] |
| AOC4P | TSG | HCC | ↓Metastasis | ↑Vimentin degradation, ↓EMT | [82] |
| MEG3 | TSG | Breast | ↓Proliferation, invasion, angiogenesis | ↓AKT pathway | [83] |
| FENDRR | TSG | NSCLC | ↓Stemness | ↓MDR1 transcription | [84] |
| LINC01133 | TSG | Colorectal | ↓Metastasis, EMT | Interacts with SRSF6 | [85] |
TSG, tumour suppressor gene; TIMP 2/3, tissue inhibitors of matrix metalloproteinases 2/3; FGF2, fibroblast growth factor-2; PD-L1, programmed death-ligand 1; VEGFA, vascular endothelial growth factor A; MMP9, matrix metalloproteinase-9; SPHK1, sphingosine kinase 1; HCC, hepatocellular carcinoma; NSCLC, non-small-cell lung carcinoma.