Figure 3.

The micropeptides Myoregulin (MLN) and Dwarf open reading frame (DWORF). DWARF RNA and MLN RNA were first identified as long non-coding RNAs (lncRNAs; Refseq numbers NR_037902 and BC069675 respectively). It appears that these two lncRNAs can encode DWORF and MLN micropeptides, respectively. Subsequently, their RefSeq category has been revised: NR_037902 became NM_001352129 and BC069675 were replaced by NM_001040109. DWORF and MLN are both involved in muscle contraction. The first one enables muscle relaxation by activating the SERCA calcium pump and thus the re-import of Ca2+ into the sarcoplasmic reticulum. Conversely, the second one maintains muscle contraction by preventing the re-import of Ca2+ by inhibiting the SERCA pump