Figure 6.

miR-199a-3p inhibitor or PAWR overexpression effectively reversed si-circMTO1-elicited GC progression. (a) BrdU incorporation assay in AGS and HGC-27 cells co-transfected by si-circMTO1 or negative control plasmid, and miR-199a-3p inhibitor or PAWR expression plasmid. (b) Flow cytometry assay of AGS and HGC-27 cells co-transfected by si-circMTO1 or negative control plasmid, and miR-199a-3p inhibitor or PAWR expression plasmid. (c, d) Transwell assays of AGS and HGC-27 cells cotransfected by si-circMTO1 or negative control plasmid, and miR-199a-3p inhibitor or PAWR expression plasmid. scale bar is 20 µm size. Data are from three independent experiments. * vs control vector group, # vs si-circMTO1 group. ##p < 0.01, **p < 0.01