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. 2020 Nov 26;2020:4607197. doi: 10.1155/2020/4607197

Figure 4.

Figure 4

The role of TRAF6 in dendritic cells. TRAF6 is a key regulator of TLR, CD40, and RANK, which regulates DC maturation and interaction with T cells. TRAF6 regulates DC maturation by upregulating the expression of B7 and MHC molecules and secreting the cytokines IL-12 and IL-6. The activated DCs interact with T cells, causing CD4+ T cells to polarize to Th1. DCs in TRAF6-deficient mice are unable to upregulate MHC and B7.2 and secrete IL-12 in response to stimulation with CD40L or various TLR ligands. Moreover, the ability of TRAF6-deficient DCs to activate antigen-specific CD4+ T cells to become IFN-γ-producing Th1 cells is insufficient. However, they have no effect on the development of Th2 cells. In addition, TRAF6 directs DCs to maintain intestinal and lung immune tolerance by balancing the induction of Tregs and Th2 cellular immunity.