Table 4.
The association between three NPAR groups and all-cause in-hospital mortality in subgroup analysis.
| Group I | Group II | Group III | |||||
|---|---|---|---|---|---|---|---|
| Characteristics | No. of patients | Ref | HR (95% CI) | P value | HR (95% CI) | P value | P value for interaction |
| Age, years | 0.104 | ||||||
| ≤72 | 450 | 1 | 2.26 (1.39, 3.70) | 0.001 | 3.98 (2.38, 6.64) | <0.001 | |
| >72 | 441 | 1 | 2.55 (1.71, 3.78) | <0.001 | 3.15 (2.05, 4.82) | <0.001 | |
| Sex | 0.673 | ||||||
| Male | 532 | 1 | 2.11 (1.42, 3.13) | <0.001 | 2.57 (1.66, 3.98) | <0.001 | |
| Female | 359 | 1 | 2.98 (1.81, 4.91) | <0.001 | 5.59 (3.34, 9.36) | <0.001 | |
| Smoking | 0.412 | ||||||
| No | 428 | 1 | 2.91 (1.92, 4.40) | <0.001 | 3.01 (1.93, 4.70) | <0.001 | |
| Yes | 463 | 1 | 2.33 (1.47, 3.69) | <0.001 | 5.01 (3.07, 8.17) | <0.001 | |
| Etiology | 0.263 | ||||||
| AMI | 671 | 1 | 3.62 (1.31, 10.01) | 0.013 | 9.10 (3.37, 24.59) | <0.001 | |
| AHF | 179 | 1 | 2.67 (1.30, 5.48) | 0.008 | 2.81 (1.72, 5.86) | 0.004 | |
| CHF | 0.188 | ||||||
| No | 701 | 1 | 2.51 (1.75, 3.61) | <0.001 | 4.67 (3.16, 6.89) | <0.001 | |
| Yes | 190 | 1 | 2.64 (1.48, 4.73) | 0.001 | 2.80 (1.53, 5.13) | 0.001 | |
| AF | 0.215 | ||||||
| No | 460 | 1 | 2.09 (1.36, 3.22) | 0.001 | 3.49 (2.20, 5.56) | <0.001 | |
| Yes | 431 | 1 | 3.16 (2.03, 4.93) | <0.001 | 4.03 (2.52, 6.45) | <0.001 | |
| CAD | 0.305 | ||||||
| No | 419 | 1 | 3.05 (1.94, 4.80) | <0.001 | 4.52 (2.82, 7.26) | <0.001 | |
| Yes | 472 | 1 | 2.13 (1.40, 3.24) | <0.001 | 3.11 (1.96, 4.95) | <0.001 | |
| Hypertension | 0.502 | ||||||
| No | 714 | 1 | 2.96 (2.06, 4.25) | <0.001 | 4.30 (2.95, 6.27) | <0.001 | |
| Yes | 177 | 1 | 1.57 (0.87, 2.82) | 0.131 | 2.38 (1.17, 4.85) | 0.017 | |
| DM | 0.890 | ||||||
| No | 559 | 1 | 2.59 (1.77, 3.79) | <0.001 | 3.22 (2.15, 4.82) | <0.001 | |
| Yes | 332 | 1 | 2.70 (1.59, 4.59) | <0.001 | 5.27 (2.98, 9.33) | <0.001 | |
| CKD | 0.807 | ||||||
| No | 651 | 1 | 2.95 (2.01, 4.34) | <0.001 | 4.44 (2.98, 6.63) | <0.001 | |
| Yes | 240 | 1 | 1.90 (1.14, 3.17) | 0.013 | 2.45 (1.34, 4.47) | 0.004 | |
| OASIS | 0.785 | ||||||
| ≤37 | 468 | 1 | 2.50 (1.61, 3.90) | <0.001 | 3.43 (2.06, 5.71) | <0.001 | |
| >37 | 423 | 1 | 2.18 (1.41, 3.35) | <0.001 | 2.96 (1.89, 4.64) | <0.001 | |
| SOFA | 0.978 | ||||||
| ≤ 7 | 491 | 1 | 2.68 (1.73, 4.14) | <0.001 | 3.81 (2.34, 6.18) | <0.001 | |
| >7 | 400 | 1 | 2.24 (1.45, 3.47) | <0.001 | 3.16 (2.00, 4.99) | <0.001 | |
| SAPS II | 0.303 | ||||||
| ≤ 47 | 464 | 1 | 3.46 (2.10, 5.71) | <0.001 | 5.14 (2.95, 8.97) | <0.001 | |
| >47 | 427 | 1 | 1.75 (1.19, 2.59) | 0.005 | 2.34 (1.55, 3.52) | <0.001 | |
| Oxygen therapy | 0.852 | ||||||
| No | 221 | 1 | 2.24 (1.20, 4.17) | 0.011 | 3.39 (1.58, 7.31) | 0.002 | |
| Yes | 670 | 1 | 2.59 (1.82, 3.70) | <0.001 | 3.65 (2.51, 5.29) | <0.001 | |
| PCI | 0.413 | ||||||
| No | 389 | 1 | 2.97 (2.10, 4.21) | <0.001 | 4.47 (3.08, 6.48) | <0.001 | |
| Yes | 502 | 1 | 1.43 (0.74, 2.74) | 0.288 | 2.17 (1.08, 4.38) | 0.030 | |
| RRT | 0.131 | ||||||
| No | 716 | 1 | 3.00 (2.08, 4.34) | <0.001 | 4.84 (3.27, 7.16) | <0.001 | |
| Yes | 175 | 1 | 1.70 (0.97, 2.97) | 0.062 | 1.84 (0.99, 3.41) | 0.054 | |
| Inotrope | 0.164 | ||||||
| No | 539 | 1 | 2.13 (1.47, 3.09) | <0.001 | 3.05 (2.02, 4.60) | <0.001 | |
| Yes | 352 | 1 | 3.57 (2.06, 6.16) | <0.001 | 5.34 (3.02, 9.44) | <0.001 | |
| Vasoconstrictor | 0.485 | ||||||
| No | 240 | 1 | 2.05 (1.17, 3.62) | 0.013 | 2.58 (1.34, 4.97) | 0.005 | |
| Yes | 651 | 1 | 2.78 (1.92, 4.02) | <0.001 | 4.13 (2.80, 6.11) | <0.001 | |
Abbreviation: NPAR: neutrophil percentage-albumin ratio; HR: hazard ratio; CI: confidence interval; BMI: body mass index; AMI: acute myocardial infarction; AHF: acute heart failure; CHF: chronic heart failure; AF: atrial fibrillation; CAD: coronary artery disease; DM: diabetes mellitus; CKD: chronic kidney disease; OASIS: Oxford Acute Severity of Illness Score; SOFA: Sequential Organ Failure Assessment; SAPS: Simplified Acute Physiology Score; PCI: percutaneous coronary intervention; RRT: renal replacement treatment.