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. 2020 Nov 26;2020:7907605. doi: 10.1155/2020/7907605

Figure 4.

Figure 4

Fibronectin expression in mouse renal tissues. (a) Immunohistochemical analysis of fibronectin expression in diabetes mellitus (DM) mouse kidney sections. Sections of DM mice exhibited high expression of fibronectin as compared to control (CON) sections. Paricalcitol treatment (DM+early P, DM+late P) decreased fibronectin expression. Magnification, ×20. (b) Representative western blots of fibronectin and GAPDH proteins extracted from mouse renal tissues. (c) Quantification of total western blots. Renal fibronectin levels were significantly increased in DM mice (n = 10) compared with control mice (n = 11) (∗∗∗p < 0.001). A significant decrease in fibronectin levels was observed in paricalcitol-treated mice (DM+early P (n = 10), DM+late P (n = 9) treatments) compared with DM mice (∗∗∗p < 0.001). Error bars correspond to SEM.