Table 2.

Methodological assessment of the RCTs included.

Study	Random description	Random method	Blinding description	Blinding method	Withdrawals/dropouts description	Inclusion/exclusion criteria	Adverse effects assessment	Statistical methods description	Total score
Foss et al. 2007 [24]	Yes	Yes	Yes	ND	Yes	Yes	No	Yes	6
McRae et al.2015 [25]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Wennberg et al. 2019 [26]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	7
Pasquier et al. 2019 [27]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	7
Godoy Monzón et al. 2010 [28]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	7
Ma et al. 2018 [29]	Yes	Yes	Yes	ND	Yes	Yes	No	Yes	5.5
Newman et al. 2013 [30]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Zhou et al. 2019 [31]	Yes	Yes	Yes	Yes	No	Yes	No	Yes	6
Cooper et al. 2019 [32]	Yes	Yes	Yes	Yes	Yes	Yes	No	No	6
Reavley et al. 2015 [33]	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	7.5
Aprato et al. 2018 [34]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	6.5
Wennberg et al. 2019 [35]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	7
Yun et al. 2009 [36]	Yes	Yes	Yes	ND	No	Yes	No	Yes	4.5
Diakomi et al. 2014 [37]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	6.5
Madabushi et al. 2016 [38]	Yes	Yes	Yes	Yes	No	Yes	No	Yes	5.5
Kacha et al. 2018 [39]	Yes	Yes	Yes	ND	No	Yes	No	Yes	5
Temelkovska-Stevanovska et al. 2014 [40]	Yes	ND	No	ND	No	Yes	No	Yes	3
Deniz et al. 2014 [41]	Yes	ND	No	ND	Yes	Yes	No	Yes	4
Bang et al. 2016 [42]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Mostafa et al. 2018 [43]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Yamamoto et al. 2019 [44]	Yes	Yes	No	ND	Yes	Yes	Yes	Yes	6
Thompson et al. 2020 [45]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	6.5
Schulte et al. 2020 [46]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Diakomi et al. 2020 [47]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	7
Mouzopoulos et al. 2009 [48]	Yes	Yes	Yes	Yes	Yes	Yes	No	Yes	6.5
Nie et al. 2015 [49]	Yes	Yes	No	ND	Yes	Yes	No	Yes	5
Hao et al. 2019 [50]	Yes	Yes	Yes	ND	Yes	Yes	No	Yes	5.5

ND: not described.