Figure 1.

Expression of IL-18 in human colon cancer tissues. (a) The mRNA expression of IL-18 in 41 normal and 274 different grades of colon cancer. The data and P values were obtained from the TCGA database. (b) The mRNA expression levels of IL-18 in 23 paired colon cancer and adjacent normal tissues were determined by real-time qPCR. (c) Western blot analysis of IL-18 protein in 4 paired colon cancer and adjacent normal tissues. (d) Expression levels of IL-18 in early onset colorectal cancer and healthy control in the Hong clinical cohort. ^∗P < 0.05, ^∗∗P < 0.01.