Table 2.
T lymphocyte Subtype Counts
| Lymphocyte subpopulation | Group | Baseline | End of surgery | 1 day | 3 days | 7 days | P value* | P value† |
|---|---|---|---|---|---|---|---|---|
| T-cells (cells/μl) | Propofol | 1256 (996–1695) | 957 (857–1032) | 722 (514–806) | 898 (615–1048) | 957 (905–1333) | 0.861 | <0.001 |
| Sevoflurane | 1285 (998–1638) | 958 (572–1513) | 775 (623–921) | 801 (526–1201) | 1307 (1059–1441) | |||
| T-helpers (cells/μl) | Propofol | 727 (556–851) | 591 (520–784) | 413 (330–442) | 533 (416–659) | 698 (659–911) | 0.818 | <0.001 |
| Sevoflurane | 786 (565–961) | 572 (451–868) | 426 (352–582) | 523 (324–734) | 832 (691–872) | |||
| Naive CD4+ cells (cells/μl) | Propofol | 169 (110–215) | 129 (80–178) | 67 (34–99) | 110 (81–150) | 181 (120–255) | 0.859 | <0.001 |
| Sevoflurane | 222 (178–317) | 177 (108–210) | 129 (88–165) | 135 (94–173) | 284 (170–351) | |||
| CM CD4+ cells (cells/μl) | Propofol | 339 (224–535) | 256 (193–364) | 186 (127–217) | 203 (181–347) | 301 (259–417) | 0.314 | <0.001 |
| Sevoflurane | 304 (213–347) | 262 (136–291) | 189 (175–215) | 200 (145–261) | 314 (250–357) | |||
| EM CD4+ cells (cells/μl) | Propofol | 131 (101–245) | 175 (120–188) | 80 (65–111) | 92 (75–171) | 121 (72–178) | 0.613 | <0.001 |
| Sevoflurane | 156 (94–216) | 140 (64–201) | 99 (59–128) | 84 (64–151) | 160 (115–236) | |||
| TEMRA CD4+ cells (cells/μl) | Propofol | 11.6 (5.9–27.7) | 12.1 (4.8–45.4) | 7.7 (2.3–44.1) | 11.2 (6.9–23.5) | 12.6 (7.2–24) | 0.772 | 0.267 |
| Sevoflurane | 14 (6.6–56.1) | 17 (3.6–55.9) | 3.5 (1.9–39.1) | 13.8 (4.4–52.8) | 8.9 (4.1–61.2) | |||
| CTL (cells/μl) | Propofol | 423 (372–573) | 387 (294–452) | 252 (183–359) | 269 (204–431) | 331 (309–404) | 0.488 | <0.001 |
| Sevoflurane | 504 (451–689) | 389 (156–606) | 356 (214–441) | 300 (189–429) | 451 (334–559) | |||
| Naive CTL (cells/μl) | Propofol | 90 (68–132) | 83 (53–127) | 48.1 (36–72) | 62 (49–69) | 75 (63–109) | 0.780 | <0.001 |
| Sevoflurane | 118 (69–147) | 79 (45–93) | 76 (58–110) | 61 (33–117) | 124 (65–142) | |||
| CM CTL (cells/μl) | Propofol | 67.4 (55–104) | 39 (30–104) | 44.1 (28.6–58.5) | 42.7 (30–81) | 54.1 (39.8–107.3) | 0.515 | 0.002 |
| Sevoflurane | 57 (39–83) | 47.3 (22.8–80.1) | 47.5 (26.1–61.6) | 37.4 (28–47.6) | 66.1 (39.1–82.2) | |||
| EM CTL (cells/μl) | Propofol | 102 (65–118) | 79 (39–148) | 59 (37–69) | 58 (47–73) | 65 (44–112) | 0.266 | 0.022 |
| Sevoflurane | 119 (98–125) | 70 (40–124) | 74 (32–138) | 61 (31–107) | 119 (74–146) | |||
| TEMRA CTL (cells/μl) | Propofol | 151 (75–281) | 148 (83–199) | 93 (60–204) | 84 (41–201) | 101 (77–220) | 0.868 | 0.011 |
| Sevoflurane | 152 (108–327) | 106 (46–200) | 110 (49–181) | 115 (45–157) | 160 (50–210) | |||
| Treg (cells/μl) | Propofol | 24.1 (16.5–41.7) | 22.4 (15–36.9) | 18.1 (14.3–23.7) | 20.1 (14.3–35.9) | 34.7 (20.4–53.1) | 0.543 | 0.002 |
| Sevoflurane | 30.2 (24.7–34.8) | 25.3 (19.5–43.4) | 21.7 (15.9–29.3) | 21 (18.7–29.3) | 33.9 (27.9–62.4) | |||
| NK cells (cells/μl) | Propofol | 169 (105–466) | 109 (67–262) | 116 (69–150) | 121 (55–223) | 148 (96–245) | 0.504 | 0.053 |
| Sevoflurane | 187 (147–453) | 166 (51–245) | 128 (71–226) | 128 (63–186) | 151 (131–206) | |||
| TNK cells (cells/μl) | Propofol | 101 (65–168) | 89 (45–103) | 72 (46–125) | 70 (25–130) | 88 (31–110) | 0.753 | 0.174 |
| Sevoflurane | 107 (69–228) | 85 (65–123) | 79 (23–127) | 76 (36–138) | 67 (25–175) |
Values are presented as median (Q1–Q3). EM: effector memory, CM: central memory, TEMRA: terminally differentiated effector memory cells, CTL: cytotoxic T lymphocytes, NK: natural killer, Treg: regulatory T lymphocytes, TNK: natural killer T lymphocytes.
*
Between-group differences in accordance with a mixed-effects model,
†
Within-group differences using a mixed-effects model.