Fig. 2.

Schematic representation of EgVIT1 membrane topology and dimer structure. A) Transmembrane domains (TMD1-5) are represented by dark blue cylinders. The helices between TMD2 and TMD3 domains, represented by light blue cylinders, conform the MBD. B) An EgVIT1 dimer representation, coloring TMDs and MBD as dark or light colors, respectively. Each protomer is colored in blue or orange. Adapted from [30]. Ct: carboxyl terminus, H: helix, MBD: metal-binding domain, Nt, amino-terminus, TMD: transmembrane domain. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)