A) Manhattan plot denoting 1,267 significant metabolic features at p<0.05, and 22 metabolic features significant at q<0.2. B) Significantly enriched metabolic pathways associated with whole body BMD Z-score. Significant metabolites over total pathway metabolites are shown in parentheses. C) Module analysis of the relationship between metabolites significantly, inversely associated with whole body BMD Z-score. Linoleic acid (C18:2), HPODE, and HODE/EpOME were all confirmed using MS/MS methods. Abbreviations: HPODE, hydroperoxy-octadecadienoic acid; HODE, hydroxyoctadecadienoic acid; EpOME, epoxyoctadecenoic acid.