Table 2.

Enriched metabolic pathways associated with microbiome-related metabolic features

Targeted metabolic feature	Metabolic pathway	Overlap size	Pathway size	p-value
Indoleacetylaldehyde	Lysine metabolism	7	22	<0.001
m/z 160.0761	Valine, leucine, and isoleucine degradation	7	23	<0.001
	TCA cycle	5	13	<0.001
	Methionine and cysteine metabolism	8	39	0.001
	Carnitine shuttle	6	27	0.001
	Arginine and proline metabolism	7	34	0.001
	Purine metabolism	7	39	0.003
	Aspartate and asparagine metabolism	9	55	0.004
	Butanoate metabolism	4	20	0.005
	Bile acid biosynthesis	7	42	0.005
	Pyrimidine metabolism	6	36	0.006
	Urea cycle/amino group metabolism	7	47	0.01
	Fatty acid activation	4	24	0.01
	Glycine, serine, alanine and threonine metabolism	6	40	0.01
	Tryptophan metabolism	7	51	0.02
	Pentose phosphate pathway	4	32	0.04
	Glycolysis and gluconeogenesis	4	33	0.04
N-Acetylputrescine	Bile acid biosynthesis	6	42	0.009
m/z 131.1181	Arginine and proline metabolism	5	34	0.01
	Carnitine shuttle	4	27	0.02