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. 2020 Nov 20;7:583965. doi: 10.3389/fvets.2020.583965

Table 3.

Minimal inhibitory concentrations (MIC50 and MIC90) of ophthalmic antibiotics for the most prevalent bacterial genera isolated in dogs with bacterial keratitis.

Staphylococcus sp. (n = 123) Streptococcus sp. (n = 68) Pseudomonas sp. (n = 44)
MIC50 MIC90 Susceptible Resistant MIC50 MIC90 Susceptible Resistant MIC50 MIC90 Susceptible Resistant
Amikacin ≤16 ≤16 98% 0% >32 >32 16% 53% ≤16 ≤16 93.2% 0.0%
Bacitracin >4 >4 0% 41% >4 >4 0% 0% >4 >4 0.0% 0.0%
Cefazolin ≤8 ≤8 7% 10% ≤8 ≤8 9% 3% >16 >16 0.0% 81.8%
Ceftiofur ≤2 ≤2 88% 7% ≤2 ≤2 99% 1% >4 >4 20.5% 79.5%
Chloramphenicol ≤4 >16 88% 12% ≤4 ≤4 100% 0% >16 >16 20.5% 77.3%
Ciprofloxacin ≤1 >4 79% 20% ≤1 2 47% 3% ≤1 ≤1 95.5% 2.3%
Doxycycline 0.25 >2 54% 0% 0.25 >2 35% 0% >2 >2 27.3% 0.0%
Erythromycin ≤0.5 >4 59% 39% ≤0.5 2 1% 15% >4 >4 0.0% 4.5%
Gentamicin ≤2 >8 72% 20% 8 >8 41% 13% ≤2 ≤2 97.7% 0.0%
Moxifloxacin ≤0.5 >1 80% 17% ≤0.5 ≤0.5 1% 0% 1 1 0.0% 0.0%
Neomycin ≤4 >8 89% 11% >8 >8 19% 79% ≤4 8 93.2% 4.5%
Ofloxacin 0.5 >1 80% 14% 1 >1 46% 0% 0.5 1 45.5% 0.0%
Oxytetracycline 1 >4 54% 22% 2 >4 63% 22% >4 >4 40.9% 38.6%
Polymyxin B 10 >10 0% 36% >10 >10 0% 56% ≤5 ≤5 0.0% 0.0%
Ticarcillin ≤16 ≤16 40% 7% ≤16 ≤16 56% 0% ≤16 64 63.6% 6.8%
Tobramycin ≤4 16 76% 14% 8 16 6% 24% ≤4 ≤4 100.0% 0.0%
Trimethoprim-Sulfamethoxazole ≤2 >2 74% 26% ≤2 ≤2 18% 0% >2 >2 18.2% 20.5%