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. 2020 Dec 4;5:280. doi: 10.1038/s41392-020-00349-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Cross talk between methionine metabolism and the other metabolism. Glycolysis produces ATP and 3-phosphoglycerate (3-PG), which are used in serine synthesis and folate cycle. ATP can be used to transform methionine into SAM. Cobalamin (Cbl) is closely related to TCA, while the methylcobalamin (MeCbl) is related to the folate cycle and methionine cycle. Glutamic acid produced by glutamine metabolism can be used in the synthesis of GSH. 3-PG 3-phosphoglycerate, Cbl cobalamin, vitamin B12, MeCbl methylcobalamin, TCA cycle tricarboxylic acid cycle