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. 2020 Nov 20;10:595502. doi: 10.3389/fcimb.2020.595502

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Copyright © 2020 Sachdeva and Sundaramurthy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Manipulation of lysosomal trafficking by Pathogen containing vacuoles. (A, B) summarizes some of the known molecular events in the interface of Mtb containing vacuole (MCV) and Salmonella containing vacuole (SCV), respectively. Pathogen effectors (shown in green) target different host factors (brown) and influence their recruitment or release on the respective PCV’s. Arrows indicate the nature of interactions. Dotted arrows show the processes that occur on a normal phagosome but are manipulated on the PCV.