Table 1.

Different pathogen and their effectors affecting host lysosomal homeostasis.

S. no	Pathogen	Effector	Effect on host lysosomes	References
1	Mtb, Mm	Esx-1 secretion system	Increases lysosomal exocytosis	(Koo et al., 2008b)
2	Mtb	ESAT-6	Increased lysosomal permeabilization	(Amaral et al., 2018)
3	Mtb	Sulfolipid-1	Increases lysosomal content of the host cell	(Sachdeva et al., 2020a)
4	Mtb	PIM6	Increases lysosomal content of the host cell	(Sachdeva et al., 2020a)
5	Salmonella	SPI-2 T3SS effector	Depletes acidic lysosomes in the host cell	(Eswarappa et al., 2010; Najibi et al., 2019)
6	Salmonella	SifA	Impairs MPR dependent trafficking of lysosomal enzymes and thereby lysosome function	(McGourty et al., 2012)
7	Salmonella	PipB2	Instigates tubulations of late endosome/lysosomes	(Knodler and Steele-Mortimer, 2005)
8	Salmonella	SifA, SpiC and SopD2	Induce aggregation of late endosome/lysosomes	(Brumell et al., 2001a; Boucrot et al., 2003; Shotland et al., 2003)
9	Staphylococcus aureus	Peptidoglycan	Increases lysosomal content of the host cell	(Najibi et al., 2019)
10	Plasmodium yoelii	Secretory effector(s)	Lysosomal exocytosis	(Vijayan et al., 2019)
11	Trypanosoma cruzi (metacyclic)	gp82 protein	Lysosome biogenesis/scattering	(Cortez et al., 2016)