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. 2020 Nov 20;8:599283. doi: 10.3389/fped.2020.599283

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Copyright © 2020 Carneiro-Sampaio, Moreira-Filho, Bando, Demengeot and Coutinho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXP3 gene structure showing the regulatory regions, the repressor domain, the zinc-finger domain, the leucine-zipper domain, the LZ-FHK loop, and the forkhead domain. The regulatory regions that are target sites for DNA methylation are indicated by blue and green arrows; and for histone modifications by green arrows. The exon localization of the mutations identified in intrauterine IPEX fetuses or neonates from 11 families is depicted. Annotations refer to coding sequence and protein alteration positions; family ID appears between parenthesis.