TABLE 2.
ALS-associated genes identified by SCAT or FUSION with 13 GTEx brain tissues.
| Tissue | N | p0 | p1 (%) | FAM66D | C9orf72 | TRIP11 | RP11-529H20.6 | ATXN3 | JUP | SCFD1 | SLC9A8 |
| Amygdala | 81 | 1,799 | 0 (0.00) | 2.85E-1 | |||||||
| Anterior cingulate cortex BA24 | 102 | 2,653 | 4 (0.15) | 1.20E-1 | 4.11E-3 | 6.90E-4 | |||||
| Caudate basal ganglia | 126 | 3,586 | 1 (0.03) | 2.71E-8 | 3.06E-1 | ||||||
| Cerebellar hemisphere | 113 | 4,327 | 6 (0.14) | 3.36E-1 | 3.93E-10 | 2.01E-1 | 2.37E-1 | 3.45E-1 | 7.25E-4 | 4.76E-2 | |
| Cerebellum | 137 | 5,752 | 4 (0.07) | 4.97E-4 | 5.86E-3 | 1.02E-2 | 1.15E-3 | 3.73E-1 | |||
| Cortex | 119 | 3,943 | 3 (0.08) | 7.79E-3 | 6.41E-3 | 2.00E-1 | 1.22E-1 | 2.00E-1 | |||
| Frontal cortex BA9 | 104 | 3,080 | 1 (0.03) | 5.87E-1 | 3.84E-16 | 1.88E-1 | |||||
| Hippocampus | 99 | 2,245 | 1 (0.04) | 3.66E-1 | 1.12E-4 | 8.61E-2 | 8.61E-2 | ||||
| Hypothalamus | 98 | 2,257 | 3 (0.13) | 4.94E-1 | 3.65E-1 | 3.65E-1 | 1.82E-2 | 1.55E-4 | 6.40E-3 | ||
| Nucleus accumbens basal ganglia | 114 | 3,172 | 2 (0.06) | 5.53E-1 | 3.32E-24 | 4.91E-3 | |||||
| Putamen basal ganglia | 98 | 2,766 | 1 (0.04) | 6.04E-7 | 2.07E-1 | ||||||
| Spinal cord cervical c-1 | 76 | 1,974 | 2 (0.10) | 4.97E-1 | 1.26E-7 | ||||||
| Substantia nigra | 70 | 1,568 | 2 (0.13) | ||||||||
| SCAT | 11469 | 8 (0.07) | 4.22E-2 | 1.08E-22 | 3.49E-2 | 4.10E-2 | 3.68E-2 | 4.22E-2 | 1.20E-3 | 4.22E-2 |
N is the sample size of gene expression in each tissue; p0 denotes the number of converged genes with heritability estimation, p1 (%) is the number (or proportion) of associated genes that have FDR < 0.05 in each tissue before adjustment of the 13 GTEx brain tissues.