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. 2020 Nov 20;11:563166. doi: 10.3389/fgene.2020.563166

FIGURE 4.

FIGURE 4

Vascular diseases: the roles of miR-21/miR-21-3p in ECs and VSMCs. Reported major signals in ECs. Brown lines: miR-21 represses RhoB to reduce migration. Purple lines: miR-21 downregulates PPARα and activates AP-1 to accelerate inflammatory response. Pink lines: miR-21 blocks PTEN and activates the PI3K/AKT/eNOS pathway to enhance NO level and decrease apoptosis. Reported major signals in VSMCs. Red lines: in neointima formation, PDGF-induced miR-21 inhibits PTEN to induce proliferation. Brown line: in arteriosclerosis obliterans, HIF-1α-induced miR-21 downregulates TPM1 to induce proliferation and migration. Pink line: TGF-β/BMP-induced miR-21 downregulates the PDCD4/AP1 pathway to promote differentiation. Green line: in hypertension, the amlodipine-activated AKT2/SP1 pathway to induce miR-21 and upregulated miR-21 downregulates the PDCD4/AP1 pathway to promote differentiation. Yellow line: in hypertension, miR-21-3p suppresses ADRA2B to reduce proliferation.