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. 2020 Nov 20;7:214. doi: 10.3389/fmolb.2020.00214

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Copyright © 2020 Koopman and Rüdiger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chaperone-mediated autophagy adaptor SQSTM1 increased in AD Heat map of autophagy markers and their adaptor proteins in different brain regions. Numbers represent the fold change in AD brains versus controls, indicated per brain region (blue gradient; white, no change; decrease, red gradient). Gray boxes represent unavailable data. FDR values are indicated as percentage. (A) General autophagy-markers do not show any significant difference, except for MAP1LC3A in the strongest affected brain regions (Hippocampus, Entorhinal Cortex and Cingulate Gyrus). Observed differences in other brain regions are non-representative due to high false discovery rate. (B) for the autophagy adaptor proteins, the protein SQSTM1 is increased in both brain regions for which data are available.