Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 20;7:214. doi: 10.3389/fmolb.2020.00214

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Koopman and Rüdiger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ubiquitin ligases largely unaffected in AD. Heat map of components of the ubiquitin ligases in different brain regions. Numbers represent the fold change in AD brains versus controls, indicated per brain region (blue gradient; white, no change; decrease, red gradient). Gray boxes represent unavailable data. FDR values are indicated as percentage. (A–C) E1, E2 and E3 ubiquitin ligases do not show any notable difference in protein levels in AD affected brain regions. (D–F) Components of the base and lid of the proteasome do not show any notable difference in protein levels in any of the brain regions. Some co-factors of the proteasome, such as Usp14 and Uch37, are slightly decreased in AD brain.