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. 2020 Nov 20;14:567404. doi: 10.3389/fncel.2020.567404

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Copyright © 2020 Manich, Gómez-López, Almolda, Villacampa, Recasens, Shrivastava, González and Castellano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of the proliferative activity of TREM2+ microglial cells after PPT. (A–F) Representative double-immunolabeled images combining TREM2 (green) and PHH3 (red) in the DG of PPT-lesioned animals at 2 dpl (A–C) and 3 dpl (D–F). Note that at both time points PHH3+ cells showed membranal TREM2 expression in the ramifications and soma of microglial cells (arrowheads). However, not all TREM2+ microglial cells with expression in their ramifications were undergoing mitosis (arrows). (G) Graph of PHH3+ cell density (cell/mm²) in NL and PPT lesioned animals after 2, 3, and 7 dpl (one-way ANOVA, time effect p < 0.0001; post hoc Tukey’s compared to NL **p < 0.01). Scale bar (A–F) = 10 μm.