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. 2020 Nov 20;7:592550. doi: 10.3389/fcvm.2020.592550

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Copyright © 2020 Ma, Liu, Zhang, Zhao, Xiong, Chang, Wang, Su, Meng and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of FTO on Ang II-induced VSMC proliferation and migration. (A) qRT-PCR detection for mRNA level of FTO in Ang II (100 nmol/L)-treated human VSMCs for 12 h. *P < 0.05 vs. Control. (B) VSMCs were transfected with si-FTO or si-Con RNA for 24 h and consequent with AngII treatment for 24 h. Western blotting assay for expression of FTO and Klf5. β-actin was used as a loading control. (C) MTT assay for proliferation of treated cell at different time points. (D) VSMCs were treated as (B) and scratch assay for cell migration. Right: statistic of migrating cells in the scratch gap. Data present mean ± SEM, n = 3. *P < 0.05 and **P < 0.01 vs. si-Con. ^#P < 0.05 vs. si-Con + AngII.