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. 2020 Jun 20;10(11):2227–2245. doi: 10.1016/j.apsb.2020.05.011

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© 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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In vivo anticancer activity of TPL@nano-gel on 4T1 xenograft model. Tumor volume changes (A), body weight changes (B), Photographs of tumors (C), final mean tumor weights (D), Kaplan–Meier survival curve (E) of mice receiving the above-indicated treatments. Expressions of apoptosis-related proteins in tumor tissue by Western Blot analysis (F). Quantitative analysis of those apoptosis-related protein expressions (G) (mean ± SD, n = 3), ∗P < 0.05 versus the control group; ^#P < 0.05, TPL@nano-gel vs. blank gel; and ^▲P < 0.05, TPL@nano-gel vs. free TPL group.