Figure 1.

Schematic illustration of C-LPNs preparation and targeted photothermal therapy (PTT) mechanism. (A) PDA core nanoparticles (PNs) were coated with a thin lipid film containing lipid-PEG-maleimide and then conjugated with the cysteine-engineered anti-CLDN3 antibody. Site-specific conjugation at the cysteine group resulted in immobilization of the antibody on the PNs surface in an orientation that maintains antigen-recognition ability. (B) CLDN3-positive tumor cells were targeted by intravenously injected C-LPNs and were ablated by high temperatures induced by NIR irradiation of C-LPNs.