Table 1.
Functional roles of 20 hub genes
| No. | Gene symbol | Full name | Function |
|---|---|---|---|
| 1 | GBP1 | Guanylate binding protein 1 | Overexpression of GBP1 promotes the progress of cervical cancer |
| 2 | IFIT2 | Interferon induced protein with tetratricopeptide repeats 2 | Low IFIT2 expression is associated with poor survival in non-small cell lung cancer. |
| 3 | IFIT1 | Interferon induced protein with tetratricopeptide repeats 1 | High expression of IFIT1 in head and neck squamous cell carcinoma is associated with poor prognosis |
| 4 | IFI44L | Interferon induced protein 44 like | IFI44L is associated with metastasis and drug resistance of liver cancer |
| 5 | MX2 | MX dynamin like GTPase 2 | MX2 is a restriction factor of hepatitis B virus replication. |
| 6 | IFI27 | Interferon alpha inducible protein 27 | Down-regulation of the IFI27 gene inhibited the proliferation of oral squamous cell carcinoma |
| 7 | IGF1 | Insulin like growth factor 1 | Association of serum IGF1 and adiponectin are involved in the metastasis of breast cancer. |
| 8 | ITGAM | Integrin subunit alpha M | ITGAM is a risk factor for systemic lupus erythematosus and may also be a protective factor for rheumatoid arthritis |
| 9 | ITPKB | Inositol-trisphosphate 3-kinase B | ITPKB may be associated with lung cancer cell metastasis |
| 10 | CSF1 | Colony stimulating factor 1 | CSF1 is involved in regulating macrophage differentiation and promoting the release of pro-inflammatory factors |
| 11 | SPP1 | Secreted phosphoprotein 1 | SPP1 is closely associated with non-small cell lung cancer, breast cancer, colorectal cancer and other cancers. |
| 12 | IL7 | Interleukin 7 | Il-7 may have anti-tumor effects |
| 13 | TNFSF10 | TNF superfamily member 10 | Viral therapy using TNFSF10 combined with plasminogen k5 may treat cancer |
| 14 | COL1A1 | Collagen type I alpha 1 chain | Down-regulation of COL1A1 expression inhibits the growth and metastasis of breast cancer cells |
| 15 | LAMB1 | Laminin subunit beta 1 | LAMB1 may be a biomarker for colorectal cancer |
| 16 | CD36 | CD36 molecule | CD36 mediates inflammation, molecular adhesion, and apoptosis |
| 17 | MDM2 | MDM2 proto-oncogene | MDM2 inhibitors may have anticancer effects. |
| 18 | THBS1 | Thrombospondin 1 | Activation of THBS1 promotes metastasis of oral squamous cell carcinoma. |
| 19 | AR | Androgen receptor | AR antagonists may be used in the treatment of breast cancer |
| 20 | FABP4 | Fatty acid binding protein 4 | FABP4 inhibitor inhibited oxidative stress in mice with acute lung injury |