Changes in neural ultrastructures using transmission electron microscopy following IHHP and cerebral ischemia/reperfusion. The red arrows indicate mitochondria, axon, gliocyte and neuron, respectively. In Sham and Intermittent hypobaric hypoxia preconditioning (IHHP) groups, glial cells and neurons were intact, organelles were rich and complete, and mitochondria and axons were structurally intact. In the ischemia/reperfusion (I/R) group, the structures of glial cells and neurons were severely damaged, and the number of mitochondria was significantly reduced. The damage of organelles and mitochondria was decreased in the IHHP+I/R group.