Table 2.

Effect of potential risk factors on PFS

Variable	Multivariate		Multivariate		Multivariate		Multivariate		Multivariate		Multivariate		Multivariate
	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value	Hazard Ratio (95% CI)	P value
Plasmacyte percentage (Continuous)	1.024 (0.9984, 1.049)	0.0669	1.0305 (1.00389, 1.0579)	0.0244	1.0211 (0.9951, 1.048)	0.113	1.0184 (0.9928, 1.045)	0.1612	1.016 (0.9879, 1.044)	0.2736	1.0138 (0.9863, 1.042)	0.329	1.0229 (0.99786, 1.049)	0.0734
ALDH (Continuous)	1.006 (1.0004, 1.012)	0.0352	1.0050 (0.99954, 1.0105)	0.0724	1.0046 (0.99873, 1.010)	0.125	1.0052 (0.9998, 1.011)	0.0606	1.006 (1.0001, 1.012)	0.0446	1.0062 (1.0005, 1.012)	0.034	1.0045 (0.99884, 1.010)	0.12
Glycolic acid (High vs. Low cutoff =0.2)			0.2521 (0.08322, 0.7639)	0.0148
L-Valine (High vs. Low cutoff =6)					0.3761 (0.09801, 1.443)	0.154
Serine (High vs. Low cutoff =6)							0.5193 (0.1618, 1.667)	0.2708
Malic acid (High vs. Low cutoff =0.03)									0.456 (0.1424, 1.461)	0.1862
L-Phenylalanine (High vs. Low cutoff =0.102)											0.4368 (0.1321, 1.445)	0.175
Xylitol (High vs. Low cutoff =0.075)													0.2789 (0.07571, 1.028)	0.055

The models consisting of clinical characteristics combined with all single significant biomarkers (selected by P<0.1) on PFS.

^ALDH, serum lactate dehydrogenase levels.