Figure 2.
ARID1A variants affect its protein levels in EOGC tumors. A. Representative images of ARID1A protein analysis in tumors with indicated ARID1A variants (Coding, Noncoding, 3’UTR and Wildtype). ARID1A immunoreactivity was detected in the nucleus, in both malignant epithelial cells and stromal cells. ARID1A protein staining in stromal lymphocytes was served as an internal positive control. All scale bars equal 50 μm. B. IHC score of ARID1A expression in tumors with indicated ARID1A variants. Data were presented as mean ± s.d. p values were analyzed by one-way ANOVA with Dunnett’s multiple comparisons test. C. ARID1A protein levels in tumors with indicated ARID1A variants. D. ARID1A variants associated with unexpected protein expression. E. Samples stratified by the number of ARID1A variants identified in tumors. F. ARID1A protein levels in tumors with indicated number of ARID1A variants. p value was calculated by χ2 test.