Table 2.
Outcomes of patients
| Parameter | Total (n = 45) | SCT (n = 17) | P (SCT vs. Chemo) | MST (n = 11) | P (SCT vs. MST) | Chemo (n = 17) | P (MST vs. Chemo) |
|---|---|---|---|---|---|---|---|
| Median time of ANC recovery (range), days | 12 (8-18) | 9 (8-14) | < .001 | 12 (10-17) | < .001 | 12 (10-18) | .462 |
| Median time of platelet recovery (range), days | 13 (6-18) | 10 (6-15) | < .001 | 13.5 (7-18) | < .001 | 13 (10-18) | .969 |
| Severe adverse event, n (%) | < .001 | < .001 | .132 | ||||
| Severe infections | 6 (13) | 2 (12) | 0 (0) | 4 (24) | |||
| III-IV aGVHD | 2 (4) | 2 (12) | 0 (0) | 0 (0) | |||
| Organ failure | 6 (13) | 6 (35) | 0 (0) | 0 (0) | |||
| Early death, n (%) | 1 (2) | 1 (6) | .476 | 0 (0) | .804 | 0 (0) | .804 |
| Total death, n (%) | 24 (53) | 11 (65) | .486 | 4 (36) | .142 | 9 (53) | .390 |
| Causes of death, n (%) | .067 | .062 | < .999 | ||||
| Relapse | 13 (27) | 2 (12) | 4 (36) | 7 (41) | |||
| Infections | 4 (9) | 3 (18) | 0 (0) | 1 (6) | |||
| GVHD | 2 (4) | 2 (12) | 0 (0) | 0 (0) | |||
| Organ failure | 5 (11) | 4 (24) | 0 (0) | 1 (6) | |||
| OS, No. of Events (%) | 24 (47) | 11 (31) | .253 | 4 (47) | .046 | 9 (24) | .022 |
| 2-year OS | 14 (69) | 10 (39) | .018 | 1 (91) | .012 | 3 (80) | .492 |
| 4-year OS | 20 (56) | 11 (31) | .159 | 1 (91) | .005 | 8 (36) | .013 |
| LFS, No. of Events (%) | 27 (40) | 11 (33) | .580 | 6 (41) | .111 | 10 (31) | .060 |
| 2-year LFS | 21 (53) | 11 (33) | .428 | 1 (91) | .005 | 9 (41) | .017 |
| 4-year LFS | 24 (47) | 11 (33) | .580 | 3 (72) | .021 | 10 (31) | .023 |
| Hematologic relapse, No. of Events (%) | 18 (40) | 3 (20) | .148 | 6 (59) | .585 | 9 (67) | .083 |
| 2-year relapse | 12 (27) | 3 (20) | .226 | 1 (9) | .429 | 8 (56) | .025 |
| 4-year relapse | 15 (33) | 3 (20) | .148 | 3 (28) | .847 | 9 (67) | .034 |
| NRM, No. of Events (%) | 9 (20) | 8 (47) | .008 | 0 (0) | .008 | 1 (6) | .421 |
| 1-year NRM | 8 (18) | 7 (41) | .019 | 0 (0) | .018 | 1 (6) | .421 |
| 2-year NRM | 9 (20) | 8 (47) | .008 | 0 (0) | .008 | 1 (6) | .421 |
Abbreviations: SCT, stem cell transplantation; MST, microtransplantation; Chemo, Chemotherapy; ANC, absolute neutrophil count; aGVHD, acute graft-versus-host disease; OS, overall survival; LFS, leukemia-free survival; NRM, non-relapse mortality.