Table 4.
Univariate and multivariate analyses for factors influencing OS, LFS and relapse (n = 45)
| Variables | 4-year OS | 4-year LFS | 4-year Relapse | |||||||||
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| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||
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| % | P | HR (95% CI) | P | % | P | HR (95% CI) | P | % | P | HR (95% CI) | P | |
| Age | ||||||||||||
| > 50 years | 75.0 | .264 | - | - | 66.7 | .215 | - | - | 16.7 | .206 | - | - |
| ≤ 50 years | 48.5 | - | - | 39.4 | - | - | 39.4 | - | - | |||
| Gender | ||||||||||||
| Male | 51.7 | .754 | - | - | 41.4 | .717 | - | - | 37.9 | .635 | - | - |
| Female | 62.5 | - | - | 56.3 | - | - | 25.0 | - | - | |||
| WBC | ||||||||||||
| ≥ 30 × 109/L | 45.8 | .112 | - | - | 37.5 | .088 | 1.465 (0.580-3.700) | .419 | 41.7 | .088 | 2.039 (0.604-6.880) | .251 |
| < 30 × 109/L | 66.7 | - | - | 57.1 | 1 | - | 23.8 | 1 | - | |||
| Chromosome type | ||||||||||||
| Ph alone | 61.1 | .101 | - | - | 50.0 | .198 | - | - | 30.6 | .227 | - | - |
| Ph with other | 33.3 | - | - | 33.3 | - | - | 44.4 | - | - | |||
| BCR-ABL transcript | ||||||||||||
| P190 | 50.0 | .333 | - | - | 43.3 | .480 | - | - | 36.7 | .440 | - | - |
| P210/P230 | 66.7 | - | - | 53.3 | - | - | 26.7 | - | - | |||
| CMR at enrollment | ||||||||||||
| Yes | 60.7 | .482 | - | - | 53.6 | .250 | - | - | 28.6 | .330 | - | - |
| No | 47.1 | - | - | 35.3 | - | - | 41.2 | - | - | |||
| TKI type at enrollment | ||||||||||||
| 1st generation | 46.7 | .181 | - | - | 36.7 | .080 | 2.049 (0.740-5.674) | .167 | 36.7 | .341 | - | - |
| 2nd generation | 73.3 | - | - | 66.7 | 1 | - | 26.7 | - | - | |||
| Time from diagnosis to enrollment | ||||||||||||
| ≥ 4 months | 45.5 | .099 | 1.483 (0.568-3.868) | .421 | 36.4 | .168 | - | - | 27.3 | .771 | - | - |
| < 4 months | 65.2 | 1 | 56.5 | - | - | 39.1 | - | - | ||||
| Treatment | ||||||||||||
| SCT | 35.3 | .005 | 1 | 35.3 | .048 | 1 | - | 17.6 | .085 | 1 | - | |
| MST | 90.9 | 0.080 (0.010-0.643) | .018 | 72.7 | 0.329 (0.078-1.396) | .132 | 27.3 | 1.126 (0.194-6.538) | .895 | |||
| Chemo | 52.9 | 0.602 (0.229-1.581) | .303 | 41.2 | 0.820 (0.345-1.949) | .654 | 52.9 | 2.750 (0.738-10.248) | .132 | |||
Abbreviations: OS, overall survival; LFS, leukemia-free survival; WBC, white blood cell; CMR, complete molecular response; TKI, tyrosine kinase inhibitor; SCT, stem cell transplantation; MST, microtransplantation; Chemo, Chemotherapy.