Table 4.
Univariate and multivariate analyses of factors associated with hepatic evens (new ascites, varices bleeding and hepatic encephalopathy) in patients with compensated cirrhosis at baseline
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
|
|
|
|||
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| Age (year) | 1.012 (0.992-1.033) | 0.236 | ||
| Sex, male vs. female | 1.193 (0.671-2.122) | 0.548 | ||
| HBeAg, yes vs. no | 0.861 (0.470-1.580) | 0.629 | ||
| NA-naïve, yes vs. no | 1.895 (0.761-4.718) | 0.169 | ||
| TDF vs. entecavir | 0.627 (0.350-1.121) | 0.115 | ||
| Diabetes mellitus, yes vs. no | 1.509 (0.878-2.594) | 0.137 | ||
| Hypertension, yes vs. no | 1.041 (0.611-1.775) | 0.881 | ||
| HBV DNA, per log10 IU/mL | 0.893 (0.757-1.054) | 0.180 | ||
| AST, per U/L | 1.000 (0.998-1.002) | 0.706 | ||
| ALT, per U/L | 0.998 (0.995-1.001) | 0.141 | ||
| Total bilirubin, per mg/dL | 1.057 (0.949-1.176) | 0.315 | ||
| Albumin, per g/L | 0.265 (0.176-0.400) | < 0.001 | 0.335 (0.217-0.517) | < 0.001 |
| INR, per ratio | 1.999 (1.040-3.843) | 0.038 | ||
| eGFR, mL/min/1.73 m2 | 0.995 (0.986-1.003) | 0.244 | ||
| Platelet, per 103/μL | 0.983 (0.978-0.989) | < 0.001 | 0.986 (0.980-0.991) | < 0.001 |
| AFP at baseline, per ng/mL | 1.001 (0.997-1.004) | 0.674 | ||
| Child-Pugh score | 1.891 (1.550-2.308) | < 0.001 | ||
| FIB-4 | 1.086 (1.053-1.120) | < 0.001 | ||
| APRI | 1.023 (0.972-1.076) | 0.389 | ||
AFP, alpha-fetoprotein; APRI, AST to platelet ratio index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; CI, confidence interval; eGFR, estimated glomerular filtration rate; FIB-4, fibrosis index based on four factors; HBV, hepatitis B virus; HBeAg, hepatitis B e antigen; INR, international normalized ratio; NA, nucleos(t)ide analogue; TDF, Tenofovir disoproxil fumarate.