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. 2020 Nov 16;219(12):e202004101. doi: 10.1083/jcb.202004101

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© 2020 Ryder et al.

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Figure 5. — FMRP regulates cen mRNA localization to centrosomes. Maximum-intensity projections of cen smFISH (magenta) in NC 13 embryos expressing GFP-γ-Tub (green). Boxed regions are enlarged at right (yellow box, zoom). (A) WT interphase embryo showing cen mRNA granules. (B) Fmr1 embryo with increased cen mRNA in pericentrosomal granules. (C) WT metaphase embryo with cen mRNA displaced from the centrosome. (D) Fmr1 embryo with cen mRNA at centrosomes. (E) Percentage of cen mRNA overlapping with centrosomes in WT versus Fmr1 embryos. (F) Percentage of cen mRNA within granules. Each dot is a single measurement from n = 27 interphase and n = 12 metaphase WT or Fmr1 NC 13 embryos; mean ± SD displayed (red). Table 1 lists number of objects quantified per condition. *, P < 0.05; ****, P < 0.0001 by unpaired t test. Scale bars: 10 µm; 2.5 µm (insets).