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. 2020 Nov 20;23(1):73. doi: 10.3892/mmr.2020.11711

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Copyright: © Ye et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of resveratrol on the PINK1/Parkin pathway in primary cortical neurons. (A) Expression levels of PINK1 and Parkin in OGD/R in the presence or absence of resveratrol were detected by immunoblotting. Effects of PINK1 or Parkin knockdown on the (B) viability and (C) apoptosis of control cells. Effects of PINK1 and Parkin silencing on (D) viability and (E) apoptosis of neurons subjected to OGD/R simulation. Data are presented as the mean ± SEM (n=3). *P<0.05 vs. the control. ^#P<0.05 vs. OGD/R. OGD/R, oxygen/glucose deprivation/reoxygenation; PINK1, phosphatase and tensin homolog-induced kinase 1; si, small interfering; NC, negative control.