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. 2020 Nov 16;23(1):51. doi: 10.3892/mmr.2020.11689

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Copyright: © Huo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Potential mechanism of the interaction between miR-21-5p and STAT3 in vitiligo. Low miR-21-5p expression may induce the differentiation of CD4⁺ T cells towards Teff cells, causing a pro-inflammatory response and thereby increasing apoptosis in melanocytes. However, miR-21-5p mimic treatment promoted the balance of Treg/Teff cells and thereby had a benefit on the survival of melanocytes. Th, T helper; IFN, interferon; IL, interleukin; miR, microRNA; Treg/Teff cells, regulatory T/effector T cells.