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. 2020 Dec 4;26:121. doi: 10.1186/s10020-020-00243-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — M3 improves cardiac function in neonatal sepsis. 16 h after cecal slurry injection, echocardiogram was performed on mouse pups. a Representative still images of B and M-mode echocardiogram findings. The B mode is the top portion of the images, while the M mode is the wave pattern, which is shown at the bottom portion of the images. b CO was reduced by sepsis induction while M3 treatment was able to ameliorate some sepsis-induced dysfunction. c Left-ventricular end diastolic diameter was reduced in vehicle-treated septic pups as compared to M3-treated pups. Data are expressed as means ± SE (sham = 9, vehicle = 6, and M3 = 7 pups). Multiple groups were compared by one-way ANOVA and Tukey method (*p < 0.05 vs. sham; ^#p < 0.05 vs. Vehicle)