Table 2.

Univariate and multivariate Cox hazard regression in TCGA cohort

Pathological type	Characteristics	Univariate analysis Hazard Ratio (95%CI)	P value	Multivariate analysis Hazard Ratio (95%CI)	P value
LUAD	EZH2 expression	1.412 (1.013–1.967)	0.041	1.386 (0.976–1.968)	0.048
	Age	1.013 (1.001–1.024)	0.026	1.029 (0.748–1.417)	0.031
	Gender	0.951 (0.684–1.323)	0.767	1.043 (0.744–1.463)	0.807
	T stage	2.619 (1.743–3.936)	0.000	1.753 (1.069–2.872)	0.026
	Lymph node metastasis	2.661 (1.906–3.713)	0.000	2.330 (1.567–3.464)	0.000
	Presence of distant metastasis	1.936 (1.092–3.434)	0.038	1.215 (0.630–2.343)	0.560
	TNM classification	2.775 (1.968–3.913)	0.000	1.365 (0.838–2.225)	0.212
	Tumor recurrence	1.315 (1.167–1.482)	0.000	1.282 (1.131–1.454)	0.000
	Smoker status	1.083 (0.826–1.419)	0.569	0.930 (0.689–1.255)	0.635
LUSC	EZH2 expression	0.966 (0.717–1.302)	0.821	0.956 (0.703–1.299)	0.773
	Age	1.196 (0.898–1.594)	0.219	1.306 (0.966–1.765)	0.083
	Gender	0.718 (0.497–1.037)	0.069	0.765 (0.528–1.109)	0.157
	T stage	1.451 (1.004–2.096)	0.056	1.111 (0.716–1.724)	0.639
	Lymph node metastasis	1.098 (0.808–1.491)	0.552	0.900 (0.623–1.301)	0.576
	Presence of distant metastasis	2.506 (0.925–6.791)	0.114	1.839 (0.632–5.351)	0.264
	TNM classification	1.546 (1.085–2.203)	0.020	1.326 (0.800–2.197)	0.274
	Tumor recurrence	1.369 (1.229–1.524)	0.000	1.343 (1.202–1.500)	0.000
	Smoker status	0.619 (0.366–1.048)	0.048	0.765 (0.528–1.109)	0.127