Table 1.
Treatment efficacy of tylvalosin (TVN) and tylosin (TYL) against natural outbreaks of enzootic pneumonia associated with M. hyopneumoniae in Hungary and France
| Study | n | Day 0 clinical cases n (% of total) |
Treatment success on study completiona | ||
|---|---|---|---|---|---|
| n (%) | Group comparison p-values |
Non inferiority p-valuesb |
|||
| Hungary | |||||
| TVN | 255 | 12 (4.7%) | 11 (91.7%) | 1.00 | 0.04 |
| TYL | 241 | 15 (6.2%) | 13 (86.7%) | ||
| France | |||||
| TVN | 183 | 18 (9.8%) | 13 (72.2%) | 0.01 | < 0.01 |
| TYL | 182 | 24 (13.2%) | 6 (25.0%) | ||
| Both sites combined | |||||
| TVN | 438 | 30 (6.8%) | 24 (80.0%) | 0.03 | < 0.01 |
| TYL | 423 | 39 (9.2%) | 19 (48.7%) | ||
M. hyopneumoniae and other bacteria including P. multocida were isolated at both sites prior to Day 0
n Number of pigs
aAbsence of treatment failures and relapses through to Day 13
bNon-inferior to control product (Farrington Manning p ≤ 0.05 indicates non inferiority to control product)