Table 2.

Metaphylactic efficacy of tylvalosin (TVN) compared with unmedicated controls (CTL) during natural outbreaks of enzootic pneumonia associated with M. hyopneumoniae in Hungary and France

	Healthy on			Frequency of new cases
	Day 0	Day 5	Day 13	Day 5–13
	n	n	n	n (%)	p-value*
Hungary
TVN	239	226	224	2 (0.9%)	0.03
CTL	219	201	192	9 (4.5%)
France
TVN	165	111	106	5 (4.5%)	0.02
CTL	157	106	91	15 (14.2%)
Both sites combined
TVN	404	340	330	7 (2.1%)	< 0.01
CTL	376	307	283	24 (7.8%)

M. hyopneumoniae and other bacteria including P. multocida were isolated at both sites prior to Day 0

* p-value from logistic model with random effect of pen in each site and random effect of site in combined analysis