Fig. 1.

Proposed pathophysiology of pseudobulbar affect. a Input from the motor, frontal, and temporal cortices to the brainstem is modulated by input from the cerebellum. Inhibitory input from the somatosensory cortex modulates the motor input. b Reduced inhibitory input (broken red arrows in the cortex) results in disinhibition, giving rise to inappropriate emotional reactions to stimuli. Permission was granted by Miller et al. (©Taylor & Francis [2]) to reuse this figure