Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 4;20:1190. doi: 10.1186/s12885-020-07680-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 5 — Knock-down of hsa_circRNA_103809 aggravated the inhibiting effects of cisplatin on cell growth in CR-NSCLC cells in vivo. The mice tumor tissues were collected, and Western Blot analysis was performed to examine the expression levels of Cyclin D1, CDK2, cleaved Caspase-3 and Bax in (a, b) A549/DDP cells (full-length blots/gels are presented in Supplementary Figure S6A-B), (c, d) H1299/DDP cells (full-length blots/gels are presented in Supplementary Figure S6C-D) and (e, f) Calu-3/DDP cells (full-length blots/gels are presented in Supplementary Figure S6E-F). g IHC was performed to examine the expressions and localization of Ki67 protein in mice tumor tissues, the signal intensity in different groups were assessed as follows: Control (+++), Cisplatin (+++), KD-circRNA (+++) and Cis + KD-circRNA (+). (Note: “Control: without vectors transfection and cisplatin treatment”). Each experiment was repeated at least 3 times. *P < 0.05