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. Author manuscript; available in PMC: 2020 Dec 4.
Published in final edited form as: Cell Rep. 2020 Nov 24;33(8):108416. doi: 10.1016/j.celrep.2020.108416

Figure 4. Global DNA Methylation Levels upon Heterozygous Loss of DNMT3A.

Figure 4.

(A and B) Global mCG (A) and mCA levels (B) in DNA isolated from brain regions of 8-week-old mice (left) (unpaired t test with Bonferroni correction) and developmental time course of global mCG in the cerebral cortex (right), as measured by sparse whole-genome bisulfite sequencing (WGBS) (p < 0.0001 effect by genotype, F(1,27) = 1024; p < 0.0001 effect by age F(5,27) = 884.6; n = 3–4; two-way ANOVA). Bonferroni corrected p values are indicated on the x axis. *p < 0.05, ***p < 0.001. Line graphs indicate mean and SEM. See also Figure S6.