Figure 7. Gene Dysregulation in DNMT3A^KO/+ Overlaps with Effects in Other NDDs.

(A) GAGE analysis of expression changes in DNMT3A^KO/+ for dysregulated gene sets in studies of NDD mouse models (Gompers et al., 2017; Katayama et al., 2016; Sessa et al., 2019; Tilot et al., 2016).

(B) GAGE analysis of expression changes in DNMT3A^KO/+ for gene sets identified in studies of human ASD. ASD modules 12 (synaptic) and 16 (immune) were identified previously in weighted gene coexpression analysis of human ASD brains (Voineagu et al., 2011), and ASD-dysregulated genes were also identified previously (Abrahams et al., 2013; Gandal et al., 2018). See also Figure S7.