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. Author manuscript; available in PMC: 2020 Dec 4.
Published in final edited form as: Neuropharmacology. 2019 Mar 21;153:142–152. doi: 10.1016/j.neuropharm.2019.03.025

Figure 5.

Figure 5.

Relative reinforcer frequency effects on cocaine preference and intake. (A) Mean (±SEM) percent choice for cocaine under the controlled reinforcer frequency procedure for an equal cocaine:food reinforcer frequency ratio (3:3), a ratio in favor of cocaine (5:1), and a ratio in favor of food (1:5); n=5/reinforcer frequency ratio condition. (B) Mean (±SEM) whole-body cocaine concentrations at reinforcer delivery under the controlled reinforcer frequency procedure for each cocaine:food frequency ratio. (C) Cocaine choices at the minimum whole-body cocaine concentration that produced cocaine-food indifference (0.18 mg/kg) under the controlled reinforcer frequency procedure for each cocaine:food reinforcer ratio. Lines are best fits of matching (Equation 1) determined by nonlinear-mixed-effects analysis.