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. 2020 Oct 30;45(1):254–264. doi: 10.3892/or.2020.7829

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Copyright: © Espinoza et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — IHC staining of TFF3. The slides were viewed by light microscopy (×40 magnification). (A) For normal colonic mucosa, TFF3 cytoplasmic staining was mainly associated with the supra- and perinuclear cytoplasm of epithelial cells in both the basal and luminal portions of the colonic crypts. Low to null staining was evident at the nuclear/globular level. (B) TFF3 was lower in cancer cells, and expressed mainly in the supra-nuclear cytoplasm. (C) Scatter plot showing that TFF3 IHC staining is mostly cytoplasmic and lower in tumors, relative to normal mucosa (P<0.0001, Mann-Whitney U test for non-matched data). (D) TFF3 expression was lower in 95.6% of available normal-tumor matching pairs (P<0.0001, Wilcoxon matched-pairs signed rank test). TFF3, trefoil factor 3; IHC, immunohistochemistry.