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. 2020 Nov 25;21(1):70. doi: 10.3892/ol.2020.12331

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — BBM disrupts the PI3K/Akt/MDM2/p53 and PI3K/Akt/mTOR signaling pathways in triple negative breast cancer cells. Cells were untreated (Ctrl) or treated with BBM (10, 20 and 40 µM). (A) Western blots were performed on both cell lines. The expression levels of (B) PI3K, (C) MDM2, (D) p-Akt/Akt, (E) COX-2, (F) LOX and (G) p53 were quantified. (H) The expression of p-mTOR was tested using an ELISA. The Ctrl group was untreated cells. Data are presented as the mean ± standard deviation (n=3). *P<0.05, **P<0.01, ***P<0.001 vs. Ctrl group. BBM, Berbamine; Ctrl, control; p-, phosphorylated-.